5 ESSENTIAL ELEMENTS FOR METHADONE NASAL SPRAY

[61] Like quite a few other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with distinctive potency. Dextromethadone, which is much less powerful being an opioid, is more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone features a lower affinity, with an IC50 o